Projects

This research project investigates the morphological and molecular diversity of astrocytes within inflammatory environments, with a specific focus on the role of Lipocalin-2 (LCN2) in astrocyte reactivity and inflammatory demyelination. Astrocytes, crucial players in central nervous system (CNS) pathology, exhibit significant functional and morphological changes under inflammatory conditions. The project utilizes innovative models of demyelination, including cuprizone and experimental autoimmune ...

Introduction: Cholestatic liver disease (CLD) is associated with intestinal barrier dysfunction. The peptide hormone ghrelin may exert both hepatoprotective and barrierstrengthening effects. Here, we have evaluated these effects under the conditions of experimental cholestasis. Methods: C57BL/6J mice with bile duct ligation (BDL) or sham surgery were treated with ghrelin or solvent for 9 days. Liver injury was assessed by histological and laboratory analyses. Paracellular macromolecule ...