Projects

Preclinical models in oncology usually comprise in vitro cell culture systems and cell line-based xenograft models. However, the vast majority of clinically evaluated substances does not achieve clinical approval, suggesting reduced meaningfulness of those model systems. Patient-derived xenograft (PDX) models are better in recapitulating the clinical situation. By using primary cells, the polyclonality of the material remains intact. Further, orthotopic transplantation sites guarantee a ...