Projects

Mittels Patientenbefragung (analog und online) wurde erfasst, wie a) das körperliche Wohlbefinden und das Bewegungsverhalten von Patienten mit MPN oder Mastozytose ist, b) welche Symptome / Nebenwirkungen / Begleiterkrankungen und Ängste die Patienten in ihrer körperlichen Aktivität einschränken sowie c) wie hoch die Motivation zu körperlicher Aktivität ist und welche Präferenzen diese Patientenkohorte hat. Ziel war es spezifische Trainingsempfehlungen für diese Patientenkohorte zu erarbeiten.

This research project investigates the morphological and molecular diversity of astrocytes within inflammatory environments, with a specific focus on the role of Lipocalin-2 (LCN2) in astrocyte reactivity and inflammatory demyelination. Astrocytes, crucial players in central nervous system (CNS) pathology, exhibit significant functional and morphological changes under inflammatory conditions. The project utilizes innovative models of demyelination, including cuprizone and experimental autoimmune ...

Preclinical models in oncology usually comprise in vitro cell culture systems and cell line-based xenograft models. However, the vast majority of clinically evaluated substances does not achieve clinical approval, suggesting reduced meaningfulness of those model systems. Patient-derived xenograft (PDX) models are better in recapitulating the clinical situation. By using primary cells, the polyclonality of the material remains intact. Further, orthotopic transplantation sites guarantee a ...

In dieser Studie soll die Assoziation/Dissoziation von Parametern der Mikro- und Makrozirkulation bei elektiven Patienten, die nach einem großen abdominalchirurgischen Eingriff auf einer Überwachungsstation behandelt werden, untersucht werden.

Introduction: Cholestatic liver disease (CLD) is associated with intestinal barrier dysfunction. The peptide hormone ghrelin may exert both hepatoprotective and barrierstrengthening effects. Here, we have evaluated these effects under the conditions of experimental cholestasis. Methods: C57BL/6J mice with bile duct ligation (BDL) or sham surgery were treated with ghrelin or solvent for 9 days. Liver injury was assessed by histological and laboratory analyses. Paracellular macromolecule ...

ATP-sensitive K+ channels are well-known for their role in insulin release in the pancreas, but they are also expressed throughout the central nervous system. Since they hyperpolarize a cell short of ATP, they directly couple the neuronal energy status to its excitability. In this project, we will disentangle the cell-specific expression of ATP-sensitive K+ channels in chronically epileptic and in control tissue using experimental epilepsy but also human resected material.