Targeting ATP-sensitive K+ channels in experimental epilepsy

Overview
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ATP-sensitive K+ channels are well-known for their role in insulin release in the pancreas, but they are also expressed throughout the central nervous system. Since they hyperpolarize a cell short of ATP, they directly couple the neuronal energy status to its excitability. In this project, we will disentangle the cell-specific expression of ATP-sensitive K+ channels in chronically epileptic and in control tissue using experimental epilepsy but also human resected material.

Programme: Universitätsmedizin Rostock (UMR)

SEEK ID: https://ldh.mediz-rostock.imise.uni-leipzig.de/projects/11

Public web page: Not specified

Organisms: No Organisms specified

NFDI4Health PIs: No PIs for this Project

Project created: 20th Nov 2024

Extended Metadata (Nfdi4Health MDS 3.3)

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Id of the project(*) : 29335

Resource classification(*)

Type of the resource(*) : Study

Title(s)/name(s) of the Project

Title/name(*) : Targeting ATP-sensitive K+ channels in experimental epilepsy
Language of the title/name(*) : English

Acronym(s) of the Project

Acronym(*) : Target-KATP
Language of the acronym(*) : English

Description(s) of the Project

Description(*) : ATP-sensitive K+ channels are well-known for their role in insulin release in the pancreas, but they are also expressed throughout the central nervous system. Since they hyperpolarize a cell short of ATP, they directly couple the neuronal energy status to its excitability. In this project, we will disentangle the cell-specific expression of ATP-sensitive K+ channels in chronically epileptic and in control tissue using experimental epilepsy but also human resected material.
Language of the description(*) : English

Keyword(s) describing the Project

Keyword(*) : Kir6, SUR1, SUR2, pilocarpine

Language(s) of the project : English

Contributor(s) of the Project

Is it a personal or organisational contribution?(*) : Organisational
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Creator/Author
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Universitätsmedizin Rostock, Oscar-Langendorff-Institut für Physiologie
Details about the contributing person(s)
Contributor type(*) : Not specified
Given name(*) : Not specified
Family name(s)(*) : Not specified
Digital identifier(s)
[]
Email address : Not specified
Phone number : Not specified
Organisation(s) associated with the contributor
Name(*) : Universitätsmedizin Rostock, Oscar-Langendorff-Institut für Physiologie
Address : Schillingallee 35, 18057, Rostock, Deutschland
Web page : https://physiologie.med.uni-rostock.de/
Digital identifier(s)
Identifier(*) : 04dm1cm79
Scheme(*) : ROR

Is it a personal or organisational contribution?(*) : Personal
Details about the contributing organisation(s)/institution(s)/group(s)
Contributor type(*) : Not specified
Funding identifier(s) : Not specified
Name of the organisation/institution/group(*) : Not specified
Details about the contributing person(s)
Contributor type(*) : Contact
Given name(*) : Timo
Family name(s)(*) : Kirschstein
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Email address : Not specified
Phone number : Not specified
Organisation(s) associated with the contributor
Name(*) : Universitätsmedizin Rostock, Oscar-Langendorff-Institut für Physiologie
Address : Schillingallee 35, 18057, Rostock, Deutschland
Web page : https://physiologie.med.uni-rostock.de/
Digital identifier(s)
Identifier(*) : 04dm1cm79
Scheme(*) : ROR
Identifier(*) : Not specified
Scheme(*) : Not specified
Name(*) : Not specified
Address : Not specified
Web page : Not specified
Digital identifier(s)
Identifier(*) : Not specified
Scheme(*) : Not specified
Identifier(*) : Not specified
Scheme(*) : Not specified

Alternative identifiers

Type of the registry(*) : Not specified
Identifier(*) : Not specified

Characteristics of the Project

Is it an interventional or non-interventional Project? : Interventional
Specification of the type of the Project
Interventional Project type : Parallel
Non-interventional Project type : []
Primary health condition(s) or disease(s) considered in the Project
Primary health condition or disease name(*) : epilepsy
Terminology/classification(*) : ICD-10
Code of the health condition or disease : G40
Groups of diseases or conditions(*)
Which groups of diseases or conditions were the data collected on? : Diseases of the nervous system (VI)
On which diseases or conditions were the data collected? : []
Collects mortality data? : Not specified
Administrative information about the Project
Status of the ethics committee approval : Request for approval not yet submitted
Overall Project status : At the planning stage
Participants enrolled by invitation? : Not specified
Start date : 1 January 2025
End date : 31 December 2026
Mono- or multicentric? : Monocentric
Number of centers : Not specified
One or more data providers? : Not specified
Number of data providers : Not specified
Primary subject(*) : Animal
Eligibility criteria for Project participants
Eligibility criteria: Minimum age
Minimum eligible age(*) : 18
Unit of age(*) : Years
Eligibility criteria: Maximum age
Maximum eligible age(*) : 70
Unit of age(*) : Years
Eligible gender : Male, Female, Diverse
Inclusion criteria : Not specified
Exclusion criteria : Not specified
Population of the Project(*)
Coverage : International
Country(ies) : Germany
Region(s) and/or city(ies) : Rostock
Interventions of the Project
Name of the intervention(*) : Casein kinase 2 inhibition
Type of the intervention : Biological/Vaccine
Additional information about the intervention : Not specified
Name(s) of the arm(s) associated with the given intervention : Not specified
Exposures of the Project
Name of the exposure : Not specified
Type of the exposure : Not specified
Additional information about the exposure : Not specified
Name(s) of the group(s) associated with the given exposure : Not specified
Outcome measures in the Project
Name of the outcome measure(*) : Not specified
Description of the outcome measure : Not specified
Type of the outcome measure : Not specified
Time point(s) of assessment : Not specified
Additional information about the Project : Not specified
Additional assessments/measurements in the Project : []
Data sharing strategy of the Project(*)
Is it planned to share the data?(*) : Yes, there is a plan to make data available
Supporting documents available in addition to the data : Study protocol, Statistical analysis plan, Analytic code
When and for how long will the data be available? : Not specified
Criteria for data access : Not specified
Additional information about data sharing : Not specified
DataSHIELD/Opal infrastructure available? : Not specified
Link to data request application : Not specified
Web page with additional information about data sharing : Not specified
Record linkage possible? : Not specified
Non-interventional aspects of the Project
Temporal design : []
Target follow-up duration of the Project
Target follow-up duration(*) : Not specified
Unit of time(*) : Not specified
Number of follow-ups conducted : Not specified
Biosamples retained in a biorepository : []
Specific types of retained biosamples : Not specified
Interventional aspects of the Project
Numerical phase : Not specified
Masking of intervention(s) assignment
Masking implemented? : Not specified
Who is masked? : []
Additional information about masking : Not specified
Type of allocation of participants to an arm : Not specified
Off-label use of a drug product : Not specified

Targeting ATP-sensitive K+ channels in experimental epilepsy

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